| 277 | GC Smith | v England at Birmingham, 1st Test, 2003 [1651] |
| 275* | DJ Cullinan | v New Zealand at Auckland, 1st Test, 1998/99 [1446] |
| 275 | G Kirsten | v England at Durban, 3rd Test, 1999/00 [1480] |
| 274 | RG Pollock | v Australia at Durban, 2nd Test, 1969/70 [671] |
| 259 | GC Smith | v England at Lord's, 2nd Test, 2003 [1653] |
| 255* | DJ McGlew | v New Zealand at Wellington, 1st Test, 1952/53 [368] |
| 236 | EAB Rowan | v England at Leeds, 4th Test, 1951 [337] |
| 231 | AD Nourse | v Australia at Johannesburg, 2nd Test, 1935/36 [248] |
| 228 | HH Gibbs | v Pakistan at Cape Town, 2nd Test, 2002/03 [1637] |
| 222* | JA Rudolph | v Bangladesh at Chittagong, 1st Test, 2003 [1640] |
| 220 | G Kirsten | v Zimbabwe at Harare, 1st Test, 2001/02 [1562] |
| 211* | HH Gibbs | v New Zealand at Christchurch, 2nd Test, 1998/99 [1449] |
| 210 | G Kirsten | v England at Manchester, 3rd Test, 1998 [1420] |
| 209 | RG Pollock | v Australia at Cape Town, 2nd Test, 1966/67 [613] |
| 208 | AD Nourse | v England at Nottingham, 1st Test, 1951 [334] |
| 204 | GA Faulkner | v Australia at Melbourne, 2nd Test, 1910/11 [112] |
| 201 | EJ Barlow | v Australia at Adelaide, 4th Test, 1963/64 [553] |
| 200 | GC Smith | v Bangladesh at East London, 1st Test, 2002/03 [1619] |
| 196 | HH Gibbs | v India at Port Elizabeth, 2nd Test, 2001/02 [1569] |
| 192 | HH Gibbs | v West Indies at Centurion, 4th Test, 2003/04 [1682] |
| 189* | B Mitchell | v England at The Oval, 5th Test, 1947 [289] |
| 189* | JH Kallis | v Zimbabwe at Bulawayo, 2nd Test, 2001/02 [1563] |
| 189 | A Melville | v England at Nottingham, 1st Test, 1947 [285] |
| 183 | HH Gibbs | v England at The Oval, 5th Test, 2003 [1659] |
| 182 | DT Lindsay | v Australia at Johannesburg, 1st Test, 1966/67 [611] |
| 180 | G Kirsten | v Sri Lanka at Durban, 1st Test, 2000/01 [1526] |
| 179 | HH Gibbs | v England at Birmingham, 1st Test, 2003 [1651] |
| 178 | AB de Villiers | v West Indies at Bridgetown, 3rd Test, 2004/05 [1749] |
| 177* | HH Dippenaar | v Bangladesh at Chittagong, 1st Test, 2003 [1640] |
| 177 | JH Kallis | v West Indies at Durban, 2nd Test, 2003/04 [1679] |
| 176 | HW Taylor | v England at Johannesburg, 1st Test, 1922/23 [148] |
| 175 | RG Pollock | v Australia at Adelaide, 4th Test, 1963/64 [553] |
| 174 | L Klusener | v England at Port Elizabeth, 2nd Test, 1999/00 [1475] |
| 168 | DJ Cullinan | v West Indies at Cape Town, 4th Test, 1998/99 [1440] |
| 164* | B Mitchell | v England at Lord's, 2nd Test, 1935 [243] |
| 163 | AC Hudson | v West Indies at Bridgetown, Only Test, 1991/92 [1188] |
| 163 | AJ Hall | v India at Kanpur, 1st Test, 2004/05 [1722] |
| 162* | WR Endean | v Australia at Melbourne, 2nd Test, 1952/53 [361] |
| 162 | JH Kallis | v England at Durban, 2nd Test, 2004/05 [1730] |
| 161 | HH Gibbs | v England at Johannesburg, 4th Test, 2004/05 [1734] |
| 160 | JH Kallis | v New Zealand at Bloemfontein, 1st Test, 2000/01 [1514] |
| 160 | G Kirsten | v Bangladesh at Potchefstroom, 2nd Test, 2002/03 [1621] |
| 158 | JH Kallis | v West Indies at Johannesburg, 1st Test, 2003/04 [1674] |
| 157* | JH Kallis | v Zimbabwe at Harare, 1st Test, 2001/02 [1562] |
| 156* | EAB Rowan | v England at Johannesburg, 2nd Test, 1948/49 [307] |
| 154* | JA Rudolph | v New Zealand at Auckland, 2nd Test, 2003/04 [1689] |
| 154 | AJ Pithey | v England at Cape Town, 3rd Test, 1964/65 [573] |
| 153* | DJ Cullinan | v India at Calcutta, 2nd Test, 1996/97 [1341] |
| 153 | G Kirsten | v Australia at Sydney, 3rd Test, 2001/02 [1582] |
